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Razvan Petrescu

Latest posts by Razvan Petrescu (see all)

  • Bariatric surgery and osteoporosis - 01/03/2017
  • Emerging approach of bone remodelling indices - 16/11/2016

Articole semnate de acelasi autor in Revista Medicala Romana:

Bariatric surgery and osteoporosis

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REVISTA MEDICALA ROMANA - Romanian Medical Journal, Vol. LXIII, Nr. 4, An 2016
ISSN 1220-5478  |  e-ISSN 2069-606X
ISSN-L 1220-5478
DOI: 10.37897/RMJ

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NEW! RMJ has announced the annually National Award for "Science and Research" for the best scientific articles published throughout the year in the official journal.

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Read the Recommendations for the Conduct, Reporting, Editing, and Publication of Scholarly work in Medical Journals.

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The published medical research literature is a global public good. Medical journal editors have a social responsibility to promote global health by publishing, whenever possible, research that furthers health worldwide.

Bariatric surgery and osteoporosis

Mara Carsote, Razvan Petrescu, Adriana Elena Nica, Adina Ghemigian, Dan Nicolae Paduraru and Ana Valea

ABSTRACT

Introduction. Bariatric surgery, regardless the type of approach, has aggressively extended nowadays. The procedure saves lives due to substantial improvement of severe cardio-metabolic co-morbidities, but the influence of nutritional status might not be completely harmless including bone and muscle changes. Our purpose is to introduce data regarding skeleton after bariatric surgery. This is a narrative mini-review including papers from PubMed. A selection of 33 papers has been done.
General data. Longitudinal better than cross-sectional studies confirmed an annual rate of losing bone mineral density at lumbar and femoral neck of 3-10% starting with first year after surgery and continuing within the third year; low vitamin D and calcium absorption with associated secondary hyperparathyroidism is described; others anomalies include elevated bone remodelling markers, damage of bone microarchitecture, fracture healing disturbances and sarcopenia.
Conclusion. Overall, despite spectacular results after bariatric surgery, the bone and muscle are expected to suffer a level of deterioration, which should be taken into account for assuring an adequate quality of life and an immediate and distant good post-operatory prognosis.

Keywords: bariatric surgery, osteoporosis, bone

Full text | PDF

Mara Carsote

Emerging approach of bone remodelling indices

SELECT ISSUE

REVISTA MEDICALA ROMANA - Romanian Medical Journal, Vol. LXIII, Nr. 3, An 2016
ISSN 1220-5478  |  e-ISSN 2069-606X
ISSN-L 1220-5478
DOI: 10.37897/RMJ

Indexed

DOI - Crossref
Similarity Check by iThenticate, worldwide No 1 professional plagiarism checking system
DOAJ
Scopus
NLM Catalog
Ebsco Host - Medline
Google Academic
Semantic Scholar

HIGHLIGHTS

National Awards “Science and Research”

NEW! RMJ has announced the annually National Award for "Science and Research" for the best scientific articles published throughout the year in the official journal.

ICMJE- Recommendations

Read the Recommendations for the Conduct, Reporting, Editing, and Publication of Scholarly work in Medical Journals.

Promoting Global Health

The published medical research literature is a global public good. Medical journal editors have a social responsibility to promote global health by publishing, whenever possible, research that furthers health worldwide.

Emerging approach of bone remodelling indices

Adina Ghemigian, Ana Valea, Mara Carsote, Otilia Radu, Razvan Petrescu and Rene Baloescu

ABSTRACT

The field of osteoporosis, especially of primary type, tidily connected with estrogen deprivation and aging, is complex and dynamic. Bone turnover markers (BTM) have been and still are a hot spot on this panorama, because no straight cut lines are found yet. We aim to briefly introduce the current status of BTM, as a short commentary. BTM have a high inter- and intra- individual variation, they are rather expensive for daily practice, they are not necessary to diagnose osteoporosis. Low or normal levels do not necessary mean that a person will not suffer fragility fracture while a higher level is associated with an increased fracture risk. Moreover, BTM seem better players for clinical studies to point out the efficacy of anti-osteoporotic drugs rather than helping each patient’s decision. BTM prematurely detect remodelling variations before DXA. No algorithm or calculation model of fracture prediction has incorporated yet BTM, most probably due to heterogeneity of reports. Traditional BTM are alkaline phosphates, osteocalcin, and collagen- derived fragments. New BTM, that proved useful, are represented by P1NP. Atypical BTM like osteoprotegerin, sclerostin, and serotonin are still far from daily practitioners’ assessment. Regardless classical or modern, the way that BTM represent a reflection of skeleton health is still an emerging subject.

Keywords: bone turnover marker, serotonin, osteoporosis

Full text | PDF

Adina Ghemigian


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