Articole semnate de acelasi autor in Revista Medicala Romana:

ASSOCIATION BETWEEN VITAMIN D DEFICIENCY AND AUTOIMMUNE DISEASES

REVISTA MEDICALA ROMANA - Romanian Medical Journal, Vol. LXI, Nr. 1, An 2014

ISSN 1220-5478 | e-ISSN 2069-606X
ISSN-L 1220-5478
DOI: 10.37897/RMJ

National Awards “Science and Research”

NEW! RMJ has announced the annually National Award for "Science and Research" for the best scientific articles published throughout the year in the official journal.

ICMJE- Recommendations

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Promoting Global Health

The published medical research literature is a global public good. Medical journal editors have a social responsibility to promote global health by publishing, whenever possible, research that furthers health worldwide.

Manole Cojocaru and Inimioara Mihaela Cojocaru

ABSTRACT
Vitamin D is a secosteroid rather than a vitamin. Vitamin D plays a role in the maintenance of immune homeostasis. Low levels of 25-hydroxyvitamin D [25(OH)D] are frequently noted in patients with autoimmune diseases, leading to a current consensus that a deficiency of the secosteroid may contribute to the autoimmune disease process. Low levels of vitamin D in patients with autoimmune disease may be a result rather than a cause of disease. The discovery of the vitamin D receptor (VDR) in the cells of the immune system and the fact that several of these cells produce the vitamin D hormone suggested that it could have immunoregulatory properties. Vitamin D has multiple immunosuppressant properties. Definitive mechanisms by which vitamin D protects against autoimmune disease have yet to be identified. This review describes the importance of vitamin D deficiency in autoimmune diseases.

Keywords: vitamin D, deficiency, pathophysiology, autoimmune diseases

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Manole Cojocaru

SERONEGATIVE ANTIPHOSPHOLIPID SYNDROME

Romanian Medical Journal | Vol. LXII, No. 1, Year 2015

ISSN 1220-5478 | e-ISSN 2069-606X
ISSN-L 1220-5478
DOI: 10.37897/RMJ

National Awards “Science and Research”

NEW! RMJ has announced the annually National Award for "Science and Research" for the best scientific articles published throughout the year in the official journal.

ICMJE- Recommendations

Read the Recommendations for the Conduct, Reporting, Editing, and Publication of Scholarly work in Medical Journals.

Promoting Global Health

Manole Cojocaru, Inimioara Mihaela Cojocaru and Bogdan Chicos

ABSTRACT

Seronegative antiphospholipid syndrome (seronegative APS) has remained an enigma and the concept is controversial. A small group of APS patients remain persistently negative for routine assays of antiphospholipid (aPL) antibodies. The clinical features are well defined, and include the tendency to both arterial and venous thrombosis, to recurrent miscarriages, and to occasional thrombocytopenia. Patients with clinical manifestations highly suggestive of APS but persistently negative conventional aPLs are classified as having seronegative APS.

Keywords: seronegative antiphospholipid syndrome, negative antiphospholipid antibodies, clinical features

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Manole Cojocaru

THE ROLE OF GENETIC FACTORS IN SPONDYLOARTHROPATIES

REVISTA MEDICALA ROMANA - Romanian Medical Journal, Vol. LXI, Nr. 3, An 2014

ISSN 1220-5478 | e-ISSN 2069-606X
ISSN-L 1220-5478
DOI: 10.37897/RMJ

National Awards “Science and Research”

NEW! RMJ has announced the annually National Award for "Science and Research" for the best scientific articles published throughout the year in the official journal.

ICMJE- Recommendations

Read the Recommendations for the Conduct, Reporting, Editing, and Publication of Scholarly work in Medical Journals.

Promoting Global Health

M. Cojocaru, Inimioara Mihaela Cojocaru and Bogdan Chicos

ABSTRACT
The spondyloarthropaties (SpAs) are chronic inflammatory diseases that involve the sacroiliac joints, axial skeleton, and, to a lesser degree, peripheral joints and certain extra-articular organs, including the eyes, skin, and cardiovascular system. Current research has demonstrated that genetics play an integral role in the development of SpAs. Genome screens have identified regions that may contain susceptibility genes for SpAs. The spondyloarthropaties are associated strongly with HLA-B27, an HLA class-I gene. Several genotypic subtypes of HLA-B27 are associated with the SpAs, with HLA-B*2705 having the strongest association. HLA-B*2702, *2703, *2704, and *2707 are also associated with ankylosing spondylitis (AS). HLA-B27-restricted CD8+ (cytotoxic) T cells may play an important role in bacterial-related SpAs such as reactive arthritis. It has been shown that the presence of the genetic marker HLA-B27 increases the likelihood of developing AS. HLA-B27 testing is of limited value. It is important to note that being HLA-B27 positive does not mean that someone will get ankylosing spondylitis (AS) nor does the gene appear in all those who have AS. The pathogenesis of SpAs is linked to a genetic predisposition (essentially HLA-B27). This article reviews the literature concerning the genetics in the most common SpAs.

Keywords: genetic disorders, spondyloarthropathies

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