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Manole Cojocaru

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Articole semnate de acelasi autor in Revista Medicala Romana:

ASSOCIATION BETWEEN VITAMIN D DEFICIENCY AND AUTOIMMUNE DISEASES

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REVISTA MEDICALA ROMANA - Romanian Medical Journal, Vol. LXI, Nr. 1, An 2014
ISSN 1220-5478  |  e-ISSN 2069-606X
ISSN-L 1220-5478
DOI: 10.37897/RMJ

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ASSOCIATION BETWEEN VITAMIN D DEFICIENCY AND AUTOIMMUNE DISEASES

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ABSTRACT
Vitamin D is a secosteroid rather than a vitamin. Vitamin D plays a role in the maintenance of immune homeostasis. Low levels of 25-hydroxyvitamin D [25(OH)D] are frequently noted in patients with autoimmune diseases, leading to a current consensus that a deficiency of the secosteroid may contribute to the autoimmune disease process. Low levels of vitamin D in patients with autoimmune disease may be a result rather than a cause of disease. The discovery of the vitamin D receptor (VDR) in the cells of the immune system and the fact that several of these cells produce the vitamin D hormone suggested that it could have immunoregulatory properties. Vitamin D has multiple immunosuppressant properties. Definitive mechanisms by which vitamin D protects against autoimmune disease have yet to be identified. This review describes the importance of vitamin D deficiency in autoimmune diseases.

Keywords: vitamin D, deficiency, pathophysiology, autoimmune diseases

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SERONEGATIVE ANTIPHOSPHOLIPID SYNDROME

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REVISTA MEDICALA ROMANA - Romanian Medical Journal, Vol. LXII, Nr. 1, An 2015
ISSN 1220-5478  |  e-ISSN 2069-606X
ISSN-L 1220-5478
DOI: 10.37897/RMJ

Indexată BDI  |  IDB Indexed

DOI - Crossref
Similarity Check by iThenticate, worldwide No 1 professional plagiarism checking system
DOAJ
Ebsco Host - Medline
Google Academic
Semantic Scholar

HIGHLIGHTS

Committe on Publication Ethics

A forum for responsible and ethical research publishing – Code of Conduct and Best Practice Guidelines for Journal Editors.

PREMIU NAȚIONAL AUTORI

RMJ și AMR oferă anual Premiul Național pentru Știință și Cercetare - pentru autorii celor mai bune articole științifice publicate [...]

Plagiatul – în actualitate

Tema plagiatului este tot mai mult discutată în ultima vreme. Apariția unor programe performante de căutare și identificare a similitudinilor între texte [...]

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SERONEGATIVE ANTIPHOSPHOLIPID SYNDROME

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ABSTRACT

Seronegative antiphospholipid syndrome (seronegative APS) has remained an enigma and the concept is controversial. A small group of APS patients remain persistently negative for routine assays of antiphospholipid (aPL) antibodies. The clinical features are well defined, and include the tendency to both arterial and venous thrombosis, to recurrent miscarriages, and to occasional thrombocytopenia. Patients with clinical manifestations highly suggestive of APS but persistently negative conventional aPLs are classified as having seronegative APS.

Keywords: seronegative antiphospholipid syndrome, negative antiphospholipid antibodies, clinical features

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