Articole semnate de acelasi autor in Revista Medicala Romana:

IN MEMORIAM – DR. VALERIA HURJUI

REVISTA MEDICALA ROMANA - Romanian Medical Journal, Vol. LXII, Nr. 3, An 2015

ISSN 1220-5478 | e-ISSN 2069-606X
ISSN-L 1220-5478
DOI: 10.37897/RMJ

ICMJE- Recommendations

Read the Recommendations for the Conduct, Reporting, Editing, and Publication of Scholarly work in Medical Journals.

Promoting Global Health

The published medical research literature is a global public good. Medical journal editors have a social responsibility to promote global health by publishing, whenever possible, research that furthers health worldwide.

Laurenţiu Şorodoc

Cuvântul domnului Prof. Dr. Laurenţiu Şorodoc, şef al Clinicii Medicină Internă II Spitalul Urgenţe Iaşi, coordonator în specialitatea de medicină internă, Universitatea de Medicină şi Farmacie „Gr. T. Popa“, Iaşi

Atotputernicul a decis să ne despărţim astăzi – pentru un timp – de doamna doctor Valeria Hurjui. Resimţim cu toţii durerea acestei pierderi. Prin cuvântul meu vă aduc mărturia unui om care a beneficiat multiplu de distinsa doamnă doctor, personalitate accentuată a medicinei româneşti, formatoare de şcoală medicală la Iaşi în domeniul, uitat în alte părţi, al toxicologiei clinice, parte a medicinei interne.

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Laurenţiu Şorodoc

CARDIOVASCULAR DISORDERS IN ACUTE DRUG INTOXICATIONS: SIX YEARS EXPERIENCE OF A TERTIARY POISON CENTER FROM ROMANIA

REVISTA MEDICALA ROMANA - Romanian Medical Journal, Vol. LXI, Nr. 3, An 2014

ISSN 1220-5478 | e-ISSN 2069-606X
ISSN-L 1220-5478
DOI: 10.37897/RMJ

ICMJE- Recommendations

Read the Recommendations for the Conduct, Reporting, Editing, and Publication of Scholarly work in Medical Journals.

Promoting Global Health

Victoriţa Şorodoc, Ovidiu Petriş, Irina M. Jaba, Cristina Bologa, Laurenţiu Şorodoc and Cătălina Lionte

ABSTRACT
Objective. To analyze the pattern of dysrhythmias and arterial blood pressure changes occurring in acute drug intoxications.

Method. Retrospective study concerning medical records from six years, regarding patients from Toxicology Clinic of Emergency Hospital of Iasi, Romania, admitted for acute drug poisoning. Arterial blood pressure values and patterns of abnormal electrocardiogram occurring in the first 6 hours after admission were analyzed.

Results. 695 cases of acute drug poisonings were analyzed. Hypertension was encountered in 6.6%, and hypotension was observed in 14.1% of the patients. Hypotension occurred in a significant percent in cardiovascular drugs (48.6%) and barbiturates poisonings (25.8%). Tachycardia was documented in 26.5% of the patients, bradycardia being found in 8.3% of the cases. Tachycardia was frequently associated with polimedication (36.8%), benzodiazepines (12.6%) followed by anticonvulsants (8.2%) and barbiturates (7.7%). Bradycardia was documented in 30.4% of the polimedication poisoning cases, 17.9% of barbiturates, 16.1% of cardiovascular drugs and 8.9% of the benzodiazepine poisoning cases. Only 14.8 % of the patients have rhythm and conduction disturbances other than tachycardia or bradycardia. On electrocardiogram, the most frequent finding was ischemia, followed by conduction abnormalities. Supraventricular arrhythmia was rarely encountered, in only 12 cases while ventricular arrhythmia was even rarest (one case of ventricular tachycardia).

Conclusion: Cardiac toxic effects were rare in acute drug poisonings cases admitted in our clinic, manifested especially as moderate clinical forms and drug-induced coma. The study did not reveal any life-threatening or cases of deaths.

Keywords: dysrhythmias, epidemiology, poisonings, drug toxicity

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Victoriţa Şorodoc

ROLUL CALCIULUI ÎN INTOXICATIA ACUTA DIGITALICA – ÎNTRE MIT SI MEDICINA BAZATA PE DOVEZI

Romanian Medical Journal | Vol. LXII, No. 2, Year 2015

ISSN 1220-5478 | e-ISSN 2069-606X
ISSN-L 1220-5478
DOI: 10.37897/RMJ

ICMJE- Recommendations

Read the Recommendations for the Conduct, Reporting, Editing, and Publication of Scholarly work in Medical Journals.

Promoting Global Health

Alexandra Rotariu, Victoriţa Şorodoc, Cristina Bologa, Ovidiu Petriş, Laurenţiu Şorodoc and Cătălina Lionte

REZUMAT

Intoxicaţia digitalică este încă frecventă în practica medicală, fie că este vorba de supradozaj acut sau cronic. Mecanismul toxicităţii este reprezentat de blocarea ATP-azei Na+/K+, urmată de creşterea Na+ intracelular şi hiperkaliemie. Hiperkaliemia creşte mortalitatea în intoxicaţia digitalică, având efect complementar toxicităţii digitalice. Sărurile de calciu sunt indicate pentru protecţie cardiacă în hiperkaliemie. Tradiţional, calciul a fost contraindicat în intoxicaţia digitalică. O analiză atentă a dovezilor existente până în prezent a demonstrat că sărurile de calciu sunt utile în tratamentul hiperkaliemiei severe, cu modificări electrocardiografice, asociate intoxicaţiei acute digitalice. În final sunt prezentate recomandările actuale de tratament în această intoxicaţie.

Cuvinte cheie: digitalice, calciu, hiperkaliemie, tratament

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